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Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors

2000; Springer Science+Business Media; Volume: 13; Issue: 4 Linguagem: Inglês

10.1007/s001470050706

1432-2277

R. Valero, C Cabrer, F. Oppenheimer, Esteve Trias, Jacinto Sánchez Ibáñez, Francisco M. De Cabo, Aurora Navarro, David Paredes, Antonio Alcaraz, Rafael Gutiérrez, Martí Manyalich,

Renal Transplantation Outcomes and Treatments

Our aim was to analyze the short- and long-term function of kidneys procured from non- heartbeating donors (NHBD) by means of three techniques: in situ perfusion (ISP), total body cooling (TBC) and normothermic recirculation (NR). Fifty-seven potential NHBD were included. Mean warm ischemia time was 68.9 +/- 35.6 min. Forty-four kidneys were obtained from donors perfused with ISP, 8 with TBC, and 8 with NR. Eighteen kidneys (32%) started functioning immediately, 29 (52%) showed delayed graft function (DGF) and 9 (16%) showed primary non function (PNF). The actuarial graft survival rate was 76.4% at 1 year and 56% at 5 years. The patient survival rate was 89.3% at 5 years. Incidence of DGF and PNF was significantly lower in kidneys perfused with NR than those with ISP or TBC (P < 0.01). Duration of DGF was shorter in kidneys obtained through TBC than in kidneys obtained with ISP (P < 0.05). In conclusion, NR reduces the incidence of DGF and may be considered the method of choice for kidney procurement from NHBD.