Produção Nacional
Revisado por pares
Increased Tissue Factor Expression and Poor Nephroblastoma Prognosis
2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 4 Linguagem: Inglês
10.1016/j.juro.2009.06.011
ISSN1527-3792
AutoresElinês Oliva Maciel, Gustavo Franco Carvalhal, Vinícius Duval da Silva, Eraldo L. Batista, Bernardo Garicochea,
Tópico(s)Chronic Kidney Disease and Diabetes
ResumoNo AccessJournal of UrologyInvestigative Urology1 Oct 2009Increased Tissue Factor Expression and Poor Nephroblastoma Prognosisis companion ofTumor Size is a Determinant of the Rate of Stage T1 Renal Cell Cancer Synchronous MetastasisGuideline for Management of the Clinical T1 Renal Mass Elinês O. Maciel, Gustavo F. Carvalhal, Vinícius D. da Silva, Eraldo L. Batista, and Bernardo Garicochea Elinês O. MacielElinês O. Maciel Department of Pediatric Surgery, Pontifícia Universidade Católica, Porto Alegre, Brazil , Gustavo F. CarvalhalGustavo F. Carvalhal Department of Urology, Pontifícia Universidade Católica, Porto Alegre, Brazil , Vinícius D. da SilvaVinícius D. da Silva Department of Pathology, Pontifícia Universidade Católica, Porto Alegre, Brazil , Eraldo L. BatistaEraldo L. Batista Department of Pathology, Pontifícia Universidade Católica, Porto Alegre, Brazil , and Bernardo GaricocheaBernardo Garicochea Department of Clinical Oncology, Pontifícia Universidade Católica, Porto Alegre, Brazil View All Author Informationhttps://doi.org/10.1016/j.juro.2009.06.011AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: There is potential interaction between malignant cell growth and the coagulation pathway. Recent studies suggest that tissue factor, a primary initiator of the extrinsic coagulation pathway, is expressed in various solid tumors in association with increased angiogenesis. To our knowledge we report for the first time the detection of tissue factor expression by immunohistochemistry in Wilms tumors and its correlation with clinical outcomes. Material and Methods: Tissue factor expression detected by immunohistochemistry was assessed in 41 formalin fixed, paraffin embedded Wilms tumor cases treated at university hospitals. We correlated findings with tumor recurrence and cancer specific survival. Results: Positive immunohistochemistry detection of tissue factor was observed in 88.3% of the tumors analyzed. Tissue factor on immunohistochemistry was associated with tumor recurrence and survival (p = 0.01 and 0.02, respectively). Increased immunohistochemical detection of tissue factor was the most important risk factor for recurrence and mortality in our population on bivariate and multivariate analysis. Conclusions: Tissue factor is a promising research subject as a prognostic factor for Wilms tumor. More studies are needed to clarify the mechanisms by which tissue factor affects cancer progression and outcome, and its potential role as a therapeutic target. References 1 : Age distribution of Wilms tumor: report from the National Wilms′ Tumor Study. Cancer Res1988; 48: 1653. Google Scholar 2 : Epidemiologic features of Wilms′ tumor: results of studies by the International Society of Pediatric Oncology (SIOP). Med Pediatr Oncol1988; 16: 7. Google Scholar 3 : Increased microvascular density predicts relapse in Wilms′ tumor. J Pediatr Surg2003; 38: 325. Google Scholar 4 : Prognostic classification of relapsing favorable histology Wilms tumor using cDNA microarray expression profiling and support vector machines. Genes Chromosomes Cancer2004; 41: 65. Google Scholar 5 : Controversies in the management of Wilms′ tumor. Semin Pediatr Surg2001; 10: 127. Google Scholar 6 : Wilms' tumor: surgical considerations and controversies. Urol Clin North Am2000; 27: 455. Google Scholar 7 : Role of tissue factor in embryonic blood vessel development. Nature1996; 383: 73. Google Scholar 8 : Tissue factor. Int J Biochem Cell Biol1998; 30: 661. Google Scholar 9 : The factor VIIa/tissue factor complex. Thromb Haemost1997; 78: 512. Google Scholar 10 : Molecular interaction between factor VII and tissue factor. Int J Hematol1998; 67: 229. Google Scholar 11 : Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol2004; 24: 1015. Google Scholar 12 : Tissue factor, thrombin, and cancer. Chest2003; 124: 58S. Google Scholar 13 : Tissue factor expression and angiogenesis in human prostate carcinoma. Hum Pathol2000; 31: 443. Google Scholar 14 : Tumor de Wilms. In: Cirurgia Pediátrica. Edited by . Rio de Janeiro: Revinter1998: 1005. Google Scholar 15 : The new SIOP (Stockholm) working classification of renal tumors of childhood: International Society of Pediatric Oncology. Med Pediatr Oncol1996; 26: 145. Google Scholar 16 : Differential apoptosis gene expression in pediatric tumors of the kidney. J Pediatr Surg2000; 35: 390. Google Scholar 17 : Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan: a report from the Study Group for pediatric Solid Malignant Tumors in the Kyushu area. Japan J Pediatr Surg2006; 41: 1501. Google Scholar 18 : National Wilms Tumor Study: an update for pathologists. Pediatr Dev Pathol1998; 1: 79. Google Scholar 19 : Immunohistochemical identification of tissue factor in solid tumors. Cancer1992; 70: 1194. Google Scholar 20 : Urinary tissue factor levels in patients with bladder and prostate cancer. Eur J Surg Oncol2000; 26: 44. Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology14 Aug 2009Tumor Size is a Determinant of the Rate of Stage T1 Renal Cell Cancer Synchronous MetastasisJournal of Urology14 Aug 2009Guideline for Management of the Clinical T1 Renal Mass Volume 182Issue 4October 2009Page: 1594-1599 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsmortalitythromboplastinkidneyprognosisWilms tumorMetricsAuthor Information Elinês O. Maciel Department of Pediatric Surgery, Pontifícia Universidade Católica, Porto Alegre, Brazil More articles by this author Gustavo F. Carvalhal Department of Urology, Pontifícia Universidade Católica, Porto Alegre, Brazil More articles by this author Vinícius D. da Silva Department of Pathology, Pontifícia Universidade Católica, Porto Alegre, Brazil More articles by this author Eraldo L. Batista Department of Pathology, Pontifícia Universidade Católica, Porto Alegre, Brazil More articles by this author Bernardo Garicochea Department of Clinical Oncology, Pontifícia Universidade Católica, Porto Alegre, Brazil More articles by this author Expand All Advertisement PDF downloadLoading ...
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