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X-ray tablet and raw diffraction as a method to study compression parameters in a direct compression excipient, compril®

1996; Elsevier BV; Volume: 144; Issue: 2 Linguagem: Inglês

10.1016/s0378-5173(96)04739-4

1873-3476

Angel Muñoz-Ruiz, Trinidad Payán Villar, Ángel Justo, Victoria Velasco, R. Jiménez-Castellanos,

Microencapsulation and Drying Processes

Abstract Compressional behavior of a direct compression excipient, Compril®, composed of a lipopolysaccharide, was studied on the basis of binding properties, plasticity, densification plot and X-ray diffraction of powder and tablet surfaces. The ratio between breaking force and mean applied force as well as plasticity of Compril® decreased when applied force was increased. The densification plot of Compril® demonstrated a non-linear relationship between ln 1/(1 -Dr) and applied pressure from low applied pressures. The increase in the slope of Heckel plot above 50 MPa may be due to densification by cold-hardening. The differences observed in integrated peak areas and full width at half maximum (FWHM) of raw material and tablets demonstrated changes in the microdomains. X-ray diffraction showed that the peaks of the tablets were narrower than in the case of the raw material, therefore a higher degree of the crystallinity of Compril® was observed when it is compacted. In this sense, the application of X-ray diffraction can clarify the consolidation mechanism of materials that deform by cold-hardening.