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BIBTEX RIS

ARRB1-Mediated Regulation of E2F Target Genes in Nicotine-Induced Growth of Lung Tumors

2011; Oxford University Press; Volume: 103; Issue: 4 Linguagem: Inglês

10.1093/jnci/djq541

ISSN

1460-2105

Autores

Piyali Dasgupta, Wasia Rizwani, Smitha Pillai, Rebecca K. Davis, Sarmistha Banerjee, Kevin T. Hug, Mark C. Lloyd, Domenico Coppola, Eric B. Haura, Srikumar Chellappan,

Tópico(s)

Pharmacological Receptor Mechanisms and Effects

Resumo

BackgroundNicotine induces the proliferation of non–small cell lung cancer (NSCLC) cells via nicotinic acetylcholine receptors and the arrestin, β1 (ARRB1) protein. However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known.

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