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Neolignans from Piper futokadsura and Their Inhibition of Nitric Oxide Production

2005; Pharmaceutical Society of Japan; Volume: 53; Issue: 1 Linguagem: Inglês

10.1248/cpb.53.121

1347-5223

Tenji Konishi, Takao Konoshima, Akihiro Daikonya, Susumu Kitanaka,

Traditional and Medicinal Uses of Annonaceae

From a MeOH extract of the aerial part of Piper futokadsura, the tetrahydrofuran lignans, futokadsurin A [(7S,8S,7′S,8′R)-3,4,3′-trimethoxy-4′-hydroxy-7,7′-epoxylignan], futokadsurin B [(7R,8R,7′R,8′S)-3,4-dimethoxy-3′,4′-methylenedioxy-7,7′-epoxylignan], and futokadsurin C [(7R,8R,7′S,8′S)-3,4-methylenedioxy-3′,4′-dimethoxy-7,7′-epoxylignan] were isolated, together with nine known neolignans. In addition, L-tryptophan, pellitorine, phytol, elemicin, and 1,2,4-trimethoxyphenyl-5-aldehyde were isolated. The structures of the new compounds were elucidated using spectroscopic methods. These lignans inhibited nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide and interferon-γ.