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Comparative Genomics of Trypanosomatid Parasitic Protozoa

2005; American Association for the Advancement of Science; Volume: 309; Issue: 5733 Linguagem: Inglês

10.1126/science.1112181

1095-9203

Najib M. El-Sayed, Peter J. Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A. Worthey, Christiane Hertz‐Fowler, Elodie Ghedin, Christopher S. Peacock, Daniella Castanheira Bartholomeu, Brian J. Haas, Anh-Nhi Tran, Jennifer R. Wortman, U. Cecilia M. Alsmark, Samuel V. Angiuoli, Atashi Anupama, Jonathan H. Badger, Frédéric Bringaud, Eithon Cadag, Jane M. Carlton, Gustavo Cerqueira, Todd Creasy, Arthur L. Delcher, Appolinaire Djikeng, T. Martin Embley, Christopher R. Hauser, Alasdair Ivens, Sarah Kummerfeld, José B. Pereira‐Leal, Daniel Nilsson, Jeremy Peterson, Steven L. Salzberg, Joshua M. Shallom, Joana C. Silva, Jaideep P. Sundaram, Scott J Westenberger, Owen White, Sara E. Melville, John E. Donelson, Björn Andersson, Kenneth Stuart, Neil Hall,

Insect symbiosis and bacterial influences

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi , and Leishmania major , three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that—along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions—have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.