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FlexServ: an integrated tool for the analysis of protein flexibility

2009; Oxford University Press; Volume: 25; Issue: 13 Linguagem: Inglês

10.1093/bioinformatics/btp304

1367-4811

Jordi Camps, Oliver Carrillo, Agustí Emperador, Laura Orellana, Adam Hospital, Manuel Rueda, Damjan Cicin-Sain, Marco D’Abramo, Josep Lluis Gelpí, Modesto Orozco,

Enzyme Structure and Function

FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann's indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.http://mmb.pcb.ub.es/FlexServ; http://www.inab.org