Revisão Revisado por pares

Oncogenes and ENT: a review of the molecular biological advances in squamous cell carcinoma of the head and neck

1993; Wiley; Volume: 18; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2273.1993.tb00801.x

ISSN

1749-4486

Autores

Louise Clark,

Tópico(s)

Cancer-related gene regulation

Resumo

Clinical Otolaryngology & Allied SciencesVolume 18, Issue 1 p. 4-13 Oncogenes and ENT: a review of the molecular biological advances in squamous cell carcinoma of the head and neck L.J. CLARK, Corresponding Author L.J. CLARK The Beatson Institute for Cancer Research, Glasgow, UKCorrespondence: L.J. Clark, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 IBD, UK.Search for more papers by this author L.J. CLARK, Corresponding Author L.J. CLARK The Beatson Institute for Cancer Research, Glasgow, UKCorrespondence: L.J. Clark, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 IBD, UK.Search for more papers by this author First published: February 1993 https://doi.org/10.1111/j.1365-2273.1993.tb00801.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Farber E. & Cameron R. (1980) The sequential analysis of cancer development. Adv. Cancer Res. 31, 125–126. 10.1016/S0065-230X(08)60658-2 CASPubMedGoogle Scholar 2 Zur Hausen, H. (1991) Viruses in human cancers. Science 254, 1167–1173. 10.1126/science.1659743 CASPubMedWeb of Science®Google Scholar 3 Gaffey M.J. & Weis L.M. (1990) Viral Oncogene& Epstein-Barr virus. Am. J. Otolaryngol. 11, 375–381. 10.1016/0196-0709(90)90115-C CASPubMedWeb of Science®Google Scholar 4 Kashima H.K., Kutcher M., Kesiss T., Levin, L.S., de Villiers, E.M. & Shah K. (1990) Human papillomavirus in squamous Cell carcinoma, leukoplakia, lichen planus and clinically normal epithelium of the oral cavity. Ann. Otol. Rhinol. Laryngol. 99, 55–61. 10.1177/000348949009900110 PubMedWeb of Science®Google Scholar 5 Batsakis J.G., Raymon A.K. & Rice D.H. (1983) The pathology of head and neck tumours: Papillomas of the upper aerodigestive tracts. Head Neck Surg. 5, 332–344. 10.1002/hed.2890050409 CASPubMedWeb of Science®Google Scholar 6 Rous P. (1911) A sarcoma of the fowl transmissible by an agent separable from the tumour cells. J. Exp. Med. 13, 397–411. 10.1084/jem.13.4.397 CASPubMedWeb of Science®Google Scholar 7 Weinberg R.A. (1989) Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res. 49, 3713–3721. CASPubMedWeb of Science®Google Scholar 8 Rothman K.J. & Kellar A.Z. (1972) The effect of joint exposure to alcohol and tobacco on the risk of cancer of the mouth and pharynx. J. Chronic Disease 25, 711–716. 10.1016/0021-9681(72)90006-9 PubMedWeb of Science®Google Scholar 9 La Vecchia, C., Boyle P., Franceschi S., Levi F., Maisonneuve P., Negri E., Lucchini F. & Smans M. (1991) Smoking and cancer with emphasis on Europe. Eur. J. Cancer 27, 94–104. 10.1016/0277-5379(91)90071-K CASPubMedWeb of Science®Google Scholar 10 Hill C., Benhamou E. & Doyon F. (1991) Trends in cancer mortality, France 1950-1985. Br. J. Cancer 63, 587–590. 10.1038/bjc.1991.136 CASPubMedWeb of Science®Google Scholar 11 Malkin D., Li F.P., Strong L.C., Fraumeni, J.F. Jr., Nelson, C.E., Kim D.H., Kassel J., Gryka M.A., Bischoff F.Z., Tainsky M.A. & Friend S.H. (1990) Germline p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms. Science 250, 1233–1238. 10.1126/science.1978757 CASPubMedWeb of Science®Google Scholar 12 Srivastava S., Zou Z.Q., Pirollo K., Blattner W. & Chang E.H. (1990) Germ-line transmission of a mutated p53 gene in a cancer prone family with Li-Fraumeni syndrome. Nature 348, 747–749. 10.1038/348747a0 CASPubMedWeb of Science®Google Scholar 13 Law J.C., Strong L.C., Chidambaram A., Ferrell R.E. (1991) A germline mutation in exon 5 of the p53 gene in an extended cancer family. Cancer Res. 51, 6385–6387. CASPubMedWeb of Science®Google Scholar 14 Li F.P. & Fraumeni, J.F. Jnr. (1969) Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. J. Nat. Cancer Inst. 43, 1365–1373. CASPubMedWeb of Science®Google Scholar 15 Riou G., Barrois M., Sheng Z.M., Duvillard P. & Lhomme C. (1988) Somatic deletions and mutations of c-Ha-ras gene in human cervical cancers. Oncogene 3, 329–333. CASPubMedWeb of Science®Google Scholar 16 Slingerland J.M. & Benchimol S. (1991) Transforming activity of mutant human p53 alleles. J. Cell Physiol. 148, 391–395. 10.1002/jcp.1041480309 CASPubMedWeb of Science®Google Scholar 17 Land H., Parada L.F. & Weinberg R.A. (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two co-operating oncogenes. Nature 304, 596–602. 10.1038/304596a0 CASPubMedWeb of Science®Google Scholar 18 Greenhalgh D.A., Welty D.J., Player A., Yuspa S.H. (1990) Two oncogenes, v-fos and v-ras, co-operate to convert normal keratinocytes to squamous cell carcinoma. Proc. Natl. Acad. Science, USA 81, 643–647. 10.1073/pnas.87.2.643 CASWeb of Science®Google Scholar 19 Murray M.J., Cunningham J.M., Parada L.F., Dautry F., Lebowitz P. & Weinberg R.A. (1983) The HL-60 transforming sequence: A ras oncogene co-existing with altered myc genes in hemopoeitic tumours. Cell 33, 749–757. 10.1016/0092-8674(83)90017-X CASPubMedWeb of Science®Google Scholar 20 Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D., D'Amico D., Bodner S., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D. & Gadzar A.F. (1992) p53 gene mutations in non small cell lung carcinoma cell lines and their correlation with presence of ras mutations and clinical features. Oncogene 7, 171–180. CASPubMedWeb of Science®Google Scholar 21 Rose E.A. (1991) Applications of the polymerase chain reaction to genome analysis. Faseb. J. 5, 46–54. 10.1096/fasebj.5.1.1991584 CASPubMedWeb of Science®Google Scholar 22 Cavenee W.K., Murphree A.L., Shull M.M., Benedict W.F., Sparkes R.S., Kock E. & Nordenskjold M. (1986) Prediction of familial predisposition to retinoblastoma. New Eng. J. Med. 314, 1201–1207. 10.1056/NEJM198605083141901 CASPubMedWeb of Science®Google Scholar 23 Cavenee W.K., Hansen M.F., Nordenskjold M., Kock E., Maumenee I., Squire J.A., Philips R.A. & Gallie B.L. (1985) Genetic origin of mutations predisposing to retinoblastoma. Science 228, 501–503. 10.1126/science.3983638 CASPubMedWeb of Science®Google Scholar 24 Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M. & Dryja T.P. (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323, 643–646. 10.1038/323643a0 CASPubMedWeb of Science®Google Scholar 25 Onadim Z., Hungerford J. & Cowell J.K. (1992) Follow-up of patients having prenatal and perinatal predictions for mutant gene carrier status using intragenic polymorphic probes from the RBI gene. Br. J. Cancer 63, 711–716. 10.1038/bjc.1992.150 Web of Science®Google Scholar 26 Saiki R.K., Gelfand D.H., Stoffel S., Scharf S.J., Higuchi R., Horn G.T., Mullis K.B. & Erlich H.A. (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487–491. 10.1126/science.2448875 CASPubMedWeb of Science®Google Scholar 27 Polak J.M. & McGee, J.O'D. (1990) In: In situ hyhridizution: principles and practice. Oxford University Press, Oxford . Google Scholar 28 Salantila A. & Budowle B. (1991) Identification Of individuals with DNA testing. Ann. Med. 23, 637–642. 10.3109/07853899109148096 CASPubMedWeb of Science®Google Scholar 29 Lindblom B., Holmlund G. & Stennek A. (1991) DNA analyses in forensic investigations (Swe) Akartidningen 88, 2055–2059. CASPubMedGoogle Scholar 30 Southern E.M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503–517. 10.1016/S0022-2836(75)80083-0 CASPubMedWeb of Science®Google Scholar 31 Kumar R. & Dunn L.L. (1989) Designed diagnostic restriction fragment length polymorphisms for the detection of point mutations in ras oncogenes. Oncogene Res. 4, 235–241. CASPubMedWeb of Science®Google Scholar 32 Saranath D., Panchal R.G., Nair R., Mehta A.R., Sanghavi V. & Deo M.G. (1990) Restriction fragment length polymorphism of the L-myc gene in oral cancer patients. Br. J. Cancer 61, 530–533. 10.1038/bjc.1990.119 CASPubMedWeb of Science®Google Scholar 33 Bos J.L. (1989) ras Oncogenes in human cancer: a review. Cancer Res. 49, 4682–4689. CASPubMedWeb of Science®Google Scholar 34 Kirsten W.H. & Mayer L.A. (1967) Morphologic responses to a murine erythroblastosis virus. J. Nat. Cancer Inst. 39, 311–335. CASPubMedWeb of Science®Google Scholar 35 Harvey J.J. (1964) An unidentified virus which causes the rapid production of tumours in mice. Nature 204, 1104–1105. 10.1038/2041104b0 CASPubMedWeb of Science®Google Scholar 36 Shimizu K., Goldfarb M., Perucho M. & Wigler M. (1983) Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc. Natl. Acad. Sci. USA 80, 383–387. 10.1073/pnas.80.2.383 CASPubMedWeb of Science®Google Scholar 37 Almoguera C., Shibata D., Forrester K., Martin J., Arnheim N. & Perucho M. (1988) Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549–554. 10.1016/0092-8674(88)90571-5 CASPubMedWeb of Science®Google Scholar 38 Corominas M., Kamino H., Leon J. & Pellicer A. (1989) Oncogene activation in human benign tumors of the skin (keratoacanthomas): is H-RAS involved in differentiation as well as proliferation? Proc. Natl. Acad. Sci. USA 86, 6372–6376. 10.1073/pnas.86.16.6372 CASPubMedWeb of Science®Google Scholar 39 Corominas M., Leon J., Kamino H., Cruz-Alvarez M., Norvick S.C. & Pellicer A. (1991) Oncogene involvement in tumour regression: H-ras activation in the rabbit keratocanthoma model. Oncogene 6, 645–651. CASPubMedWeb of Science®Google Scholar 40 Saranath D., Chang S.E., Bhoite L.T., Panchal R.G., Kerr I.B., Mehta A.R., Johnson N.W. & Deo M.G. (1991) High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral cancer in India. Br. J. Cancer 63, 573–578. 10.1038/bjc.1991.133 PubMedWeb of Science®Google Scholar 41 Rumsby G., Carter R.L. & Gusterson B.A. (1990) Low incidence of ras oncogene activation in human squamous cell carcinomas. Br. J. Cancer 61, 365–368. 10.1038/bjc.1990.80 CASPubMedWeb of Science®Google Scholar 42 Brown K., Buchmann A. & Balmain A. (1990) Carcinogen induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumour progression. Proc. Natl. Acad. Sci. USA 87, 538–542. 10.1073/pnas.87.2.538 CASPubMedWeb of Science®Google Scholar 43 Henrard D.R., Thornley A.T., Brown M.L. & Rheinwald J.G. (1990) Specific effects of ras oncogene expression on the growth and histogenesis of human epidermal keratinocytes. Oncogene 5, 475–481. CASPubMedWeb of Science®Google Scholar 44 Daftary D.K. (1990) The situation in high risk areas of the world. In: Risk markers for oral diseases. Vol 2, N.W. Johnson, (Ed.) Cambridge University Press, Cambridge . Google Scholar 45 Gupta P.C., Mehta F.S., Pindeberg J.J., Ahgi M.B., Bhonsle R.B. & Murti P.R. (1987) An educational intervention study for tobacco chewing and smoking among Indian villagers. In: Smoking and health, A.M. Hisamichi & S. Tominaga, (eds.) Excerpta Medica, Amsterdam . Google Scholar 46 Jussawalla D.J. & Deshapande D.S. (1971) Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment. Cancer 28, 244–252. 10.1002/1097-0142(197107)28:1 3.0.CO;2-H CASPubMedWeb of Science®Google Scholar 47 Peto R., Lopez A.D., Boreham J., Thun M. & Heath, C. Jr. (1992) Mortality from tobacco in developed countries: indirect estimation from national vital statistics. Lancet 339, 1268–1278. 10.1016/0140-6736(92)91600-D CASPubMedWeb of Science®Google Scholar 48 Sigurdur I. (1990) The myc gene family proteins and their role in transformation and differentiation. Sem. Can. Biol. 1, 359–369. Google Scholar 49 Yokata J., Tsunetsugu-Yokota Y., Battifora H., Le-Fevre C. & Cline M.J. (1986) Alterations of myc, myb and rasHaproto-oncogenes in cancers are frequent and show clinical correlation. Science 231, 261–265. 10.1126/science.3941898 CASPubMedWeb of Science®Google Scholar 50 Field J.K., Spandidos D.A., Stell P.M., Vaughan E.D., Evan G.I. & Moore J.P. (1989) Elevated expression of the c-myc oncoprotein oncoprotein correlates with poor prognosis in head and neck squamous cell carcinoma. Oncogene 4, 1463–1469. PubMedWeb of Science®Google Scholar 51 Field J.K., Lamothe A. & Spandidos D.A. (1986) Clinical relevance of oncogene expression in head and neck tumours. Anti-cancer Res. 6, 595–600. PubMedWeb of Science®Google Scholar 52 Cole M.D. (1986) The myc oncogene: its role in transformation and differentiation. Ann. Rev. Genet. 20, 361–384. 10.1146/annurev.ge.20.120186.002045 CASPubMedWeb of Science®Google Scholar 53 Cohen S., Ushiro H., Stoscheck C., Chinkers M. (1982) A native 170 000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J. Biol. Chem. 257, 1523–1531. CASPubMedWeb of Science®Google Scholar 54 Carpenter G. & Cohen S. (1979) Epidermal growth factor. Annu. Rev. Biochem. 48, 193–216. 10.1146/annurev.bi.48.070179.001205 CASPubMedWeb of Science®Google Scholar 55 Cohen S. (1983) The epidermal growth factor (EGF) Cancer 51, 1787–1791. 10.1002/1097-0142(19830515)51:10 3.0.CO;2-A CASPubMedWeb of Science®Google Scholar 56 Todaro G.J., Fryling C., De Larco, J.E. (1980) Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc. Natl. Acad. Sci. USA 77, 5258–5262. 10.1073/pnas.77.9.5258 CASPubMedWeb of Science®Google Scholar 57 Massacue J. (1983) Epidermal growth factor-like transforming growth factor: 11. Interaction with epidermal growth factors in human placenta membranes and A431 cells. J. Biol. Chem. 258, 13614–13620. PubMedWeb of Science®Google Scholar 58 De Larco J.E. & Todaro G.J. (1978) Growth factor from murine sarcoma virus-transformed cells. Proc. Natl. Acad. Sci. USA 75, 4001–4005. 10.1073/pnas.75.8.4001 CASPubMedWeb of Science®Google Scholar 59 Ozanne B., Fulton R.J. & Kaplan P.L. (1980) Kirsten murine sarcoma virus-transformed cell lines and a spontaneously transformed rat cell line produce transforming factors. J. Cell. Physiol. 105, 163–180. 10.1002/jcp.1041050118 CASPubMedWeb of Science®Google Scholar 60 Twardzik D.R., Todaruo J., Marquardt H., Reynolds F.H. & Stephenson J.R. (1982) Transformation induced by Abelson murine leukaemia virus involves production of a polypeptide growth factor. Science 216, 894–897. 10.1126/science.6177040 CASPubMedWeb of Science®Google Scholar 61 Cohen S. (1962) Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J. Biol. Chem. 237, 1555–1562. 10.1016/S0021-9258(19)83739-0 CASPubMedWeb of Science®Google Scholar 62 Rheinwald J.G. & Green H. (1977) Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 265, 421–424. 10.1038/265421a0 CASPubMedWeb of Science®Google Scholar 63 Wille, J.J. Jr., Pittelkow, M.R., Shipley G.D. & Scott R.E. (1984) Integrated control of growth and differentiation of normal human prokeratincytes cultured in serum-free medium: clonal analyses, growth kinetics and cell cycle studies. J. Cell. Physiol. 121, 31–34. 10.1002/jcp.1041210106 CASPubMedWeb of Science®Google Scholar 64 King I. & Sartorelli A.C. (1989) Epidermal growth factor receptor gene expression, protein kinase activity and terminal differentiation of human malignant epithelial cells. Cancer Res. 49, 5677–5681. CASPubMedWeb of Science®Google Scholar 65 Limas C. (1991) Relationship of epidermal growth factor receptor detectability with the A, B, H blood group antigens. Emphasis on normal and neoplastic urothelium. Am. J. Path. 139, 131–137. CASPubMedWeb of Science®Google Scholar 66 Partridge M., Gullick W.J., Langdon J.D. & Sherriff M. (1988) Expression of epidermal growth factor receptor on oral squamous cell carcinoma. Br. J. Oral Maxillofac. Surg. 26, 381–389. 10.1016/0266-4356(88)90090-3 CASPubMedWeb of Science®Google Scholar 67 Cowley G., Smith J.A., Gusterson B., Hendler F. & Ozanne B. (1984) The amount of EGF receptor is elevated on squamous cell carcinomas. Cancer Cells 1, 5–10. CASGoogle Scholar 68 Santini J., Formento J.L., Francoual M., Milano G., Schneider M., Dassonville O. & Demard F. (1991) Characterisation, quantification and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas. Head Neck 13, 132–139. 10.1002/hed.2880130209 CASPubMedWeb of Science®Google Scholar 69 Kawamoto T., Takahasi K., Nishi M., Kimura T., Matsumura T. & Taniguchi S. (1991) Quantitative assay of epidermal growth factor receptor in human squamous cell carcinomas of the oral region by an avidin-biotin method. J. J. Cancer Res. 82, 403–410. 10.1111/j.1349-7006.1991.tb01863.x CASPubMedWeb of Science®Google Scholar 70 Xiong Y., Connolly T., Futcher B. & Beach D. (1991) Human D-type cyclin. Cell 65, 691–699. 10.1016/0092-8674(91)90100-D CASPubMedWeb of Science®Google Scholar 71 Lammie G.A., Fantl V., Smith R., Schuuring E., Brookes S., Michalides R., Dickson C., Arnold R. & Peters G. (1991) D11S287, a putative oncogene on chromosome Ilq 13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene 6, 439–444. CASPubMedWeb of Science®Google Scholar 72 Jianc W., Kahn S.M., Tomita N., Zhang Y.J., Lu S-H. & Weinstein I.B. (1992) Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res. 52, 2980–2983. PubMedWeb of Science®Google Scholar 73 Somers K.D., Cartwricht S.L. & Schechter G.L. (1990) Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene 5, 915–920. CASPubMedWeb of Science®Google Scholar 74 Merritt W.D., Weissler M.C., Turk B.F. & Gilmer T.M. (1990) Oncogene amplification in squamous cell carcinoma of the head and neck. Arch. Otolaryngol. Head Neck Surg. 116, 1394–1398. 10.1001/archotol.1990.01870120040005 PubMedWeb of Science®Google Scholar 75 Zong Y.S., Sham J.S., Ng M.H., Ou X.T., Guo Y.Q., Zheng S.A., Liang J.S. & Qui H. (1992) Immunoglobulin A against viral capsid antigen of Epstein-Barr virus and indirect mirror examination of the nasopharynx in the detection of asymptomatic nasopharyngedl carcinoma. Cancer 69, 3–7. 10.1002/1097-0142(19920101)69:1 3.0.CO;2-7 PubMedGoogle Scholar 76 Feinmesser R., Miyazaki I., Cheung R., Freeman J.L., Noyek A.M. & Dosch H.M. (1992) Diagnosis of nasopharyngeal carcinoma by DNA amplification of tissue obtained by tine needle aspiration. New Eng. J. Med. 326, 17–21. 10.1056/NEJM199201023260103 CASPubMedWeb of Science®Google Scholar 77 Okano M., Thiele G.M., Davis J.R., Grierson H.L. & Purtilo D.T. (1988) Epstein-Barr virus and human diseases: recent advances in diagnosis. Clin. Microbiol. Reviews 1, 300–312. 10.1128/CMR.1.3.300 PubMedGoogle Scholar 78 Syrjanen K.J. (1987) Review: human papillomavirus (HPV) infections and their associations with squamous cell neoplasia. Arch. Geschwulstforsch. 57, 417–444. CASPubMedGoogle Scholar 79 Lindeberg H., Fey S.J., Ottosen P.D., Mose Larsen, P. (1988) Human papilloma virus (HPV) and carcinomas of the head and neck. Clin. Otolaryngol. 13, 447–454. 10.1111/j.1365-2273.1988.tb00318.x PubMedWeb of Science®Google Scholar 80 Maitlnd N.J., Cox M.F., Lynas C., Prime S.S., Meanwell C.A. & Scully C. (1987) Detection of human papillomavirus DNA in biopsies of human oral tissue. Br. J. Cancer 56, 245–250. 10.1038/bjc.1987.185 PubMedWeb of Science®Google Scholar 81 Hurlin P.J., Kaur P., Smith P.P., Perez-Reyes N., Blanton, R. A. & Mcdougall J.K. (1991) Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype. Proc. Natl. Acad. Sci. USA 88, 570–574. 10.1073/pnas.88.2.570 CASPubMedWeb of Science®Google Scholar 82 Pirisi L., Yasumoto S., Feller M., Doniger J & Dipaulo J. (1987) Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol. 61, 1061–1066. 10.1128/JVI.61.4.1061-1066.1987 CASPubMedWeb of Science®Google Scholar 83 Park N.H., Min B.M., Li S.L., Huanc M.Z., Cherick H.M. & Donicer J. (1991) Immortalization of normal human oral keratinocytes with type 16 human papillomavirus. Carcinogenesis 12, 1627–1631. 10.1093/carcin/12.9.1627 CASPubMedWeb of Science®Google Scholar 84 Munger K., Phelps W.C., Bubb V., Howley P.M. & Schlegel R. (1989) The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63, 4417–4421. 10.1128/jvi.63.10.4417-4421.1989 CASPubMedWeb of Science®Google Scholar 85 Hawley-Nelson P., Vousden K.H., Hubbert N.L., Lowy D.R. & Schiller J.T. (1989) Hpv 16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. Embo J. 8, 3905–3910. 10.1002/j.1460-2075.1989.tb08570.x CASPubMedWeb of Science®Google Scholar 86 Howley P.M. (1991) Role of the human papillomavirus in human cancer. Cancer Res. Suppl. 51, 5019–5022. CASPubMedWeb of Science®Google Scholar 87 Werness B.A., Levine A.J. & Howley P.M. (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76–79. 10.1126/science.2157286 CASPubMedWeb of Science®Google Scholar 88 Scheffner M., Muncer K., Byrne J.C. & Hdwley P.M. (1991) The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA 88, 5523–5527. 10.1073/pnas.88.13.5523 CASPubMedWeb of Science®Google Scholar 89 Crook T., Tidy J.A. & Vousden K.H. (1991) Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell 67, 547–556. 10.1016/0092-8674(91)90529-8 CASPubMedWeb of Science®Google Scholar 90 Munger K., Werness B.A., Dyson N., Phelps W.C., Harlow E. & Howley P.M. (1989) Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumour suppressor gene product. Embo J. 8, 4099–4105. 10.1002/j.1460-2075.1989.tb08594.x PubMedWeb of Science®Google Scholar 91 Bradford C.R., Zacks S.E., Androphy E.J., Grecoire L., Lancaster W.D. & Carey T.E. (1991) Human papillomavirus Dna sequences in cell lines derived from head and neck squamous cell carcinomas. Otolaryngol. Head Neck Surg. 104, 303–310. 10.1177/019459989110400304 CASPubMedWeb of Science®Google Scholar 92 Chiba I., Takahasi T., Nau M.M., D'Amico D., Curiel D.T., Mitsudomi T., Buchhagen D.L., Carbone D., Piantadosi S., Koga, H., Reissman, P.T., Slamon D.J., Holmes E.C. & Minna J.D. (1990) Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene 5, 1603–1610. CASPubMedWeb of Science®Google Scholar 93 Maitland N.J., Bromidge T., Cox M.F., Crane I.J., Prime S.S. & Scully C. (1989) Detection of human papillomavirus genes in human oral tissue biopsies and cultures by polymerase chain reaction. Br. J. Cancer 59, 698–703. 10.1038/bjc.1989.146 CASPubMedWeb of Science®Google Scholar 94 Yeudall W.A. & Campo M.S. (1991) Human papillomavirus DNA in biopsies of oral tissues J. Gen. Virol. 72, 173–176. 10.1099/0022-1317-72-1-173 CASPubMedWeb of Science®Google Scholar 95 Hollstein M.C., Metcalf R.A., Welsh J.A., Montesano R. & Harris C.C. (1990) Frequent mutation of the p53 gene in human esophageal cancer. Proc. Natl. Acad. Sci. USA 87, 9958–9961. 10.1073/pnas.87.24.9958 CASPubMedWeb of Science®Google Scholar 96 Crook T., Wrede D., Tidy J., Scholefield J., Crawford L. & Vousden K.H. (1991) Status of c-myc, p53 and retinoblastomd genes in the human papillomavirus positive and negative squamous cell carcinomas of the anus. Oncogene 6, 1251–1257. CASPubMedWeb of Science®Google Scholar 97 Brash D.E., Rudolph J.A., Simon J.A., Ian A., Mckenna G.J., Baven H.P., Halperin A.J. & Ponten J. (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. Usa 88, 10124–10128. 10.1073/pnas.88.22.10124 CASPubMedWeb of Science®Google Scholar 98 Pierceall W.E., Mukhopadhyay T., Goldberg L.H. & Ananthaswamy H.N. (1991) Mutations in the p53 tumour suppressor gene in human cutaneous squamous cell carcinomas. Mol. Carcinogenesis 4, 445–449. 10.1002/mc.2940040606 CASPubMedWeb of Science®Google Scholar 99 Field J.K., Spandidos D.A., Malliri A., Gosney J.R., Yiagnisis M. & Stell P.M. (1991) Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck. Br. J. Cancer 64, 573–577. 10.1038/bjc.1991.352 CASPubMedWeb of Science®Google Scholar 100 Gusterson B.A., Anbazhagen R., Warren W., Midgely C., Lane D.P., O'Hare M., Stamps A., Carter R. & Jayatilake H. (1991) Expression of p53 in premalignant and malignant squamous epithilium. Oncogene 6, 1785–1789. PubMedWeb of Science®Google Scholar 101 Sakai E. & Tsuchida N. (1992) Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumour-suppressor genes. Oncogene 7, 927–933. CASPubMedWeb of Science®Google Scholar 102 Maestro R., Dolcetti R., Gasparotto D., Doclioni C., Pelucchi S., Barzan L., Grandi E. & Boiochi M. (1992) High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene 7, 1159–1166. CASPubMedWeb of Science®Google Scholar 103 Baker S.J., Markowitz S., Fearon E.R., Willson J.K. & Vogelstein B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249, 912–915. 10.1126/science.2144057 CASPubMedWeb of Science®Google Scholar 104 Huang H., Yee J., Shew J., Chen P., Bookstein R., Freidman T., Lee E. & Lee W. (1988) Suppression of the neoplastic phenotype by replacement of the Rb gene in human cancer cells. Science 242, 1563–1566. 10.1126/science.3201247 CASPubMedWeb of Science®Google Scholar 105 Finlay C.A., Hinds P.W. & Levine A.J. (1989) The p53 proto-oncogene can act as a suppressor of transformation. Cell 57, 1083–1093. 10.1016/0092-8674(89)90045-7 CASPubMedWeb of Science®Google Scholar 106 Burns J.E., Baird M.C., Clark L.J., Burns P., Edington K., Chapman C., Mitchell R., Robertson G., Soutar D. & Parkinson E.K. (1992) Gene mutations and elevated levels of p53 protein in human squamous cell carcinomas and their cell lines. Br. J. Cancer (in press). Google Scholar 107 Halevy O., Michalovitz D. & Oren M. (1990) Different tumor-derived p53 mutants exhibit distinct biological activities. Science 250, 113–116. 10.1126/science.2218501 CASPubMedWeb of Science®Google Scholar 108 Casson A.G., Mukhopadhyay T., Cleary K.R., Ro J.Y., Levine B. & Roth J.A. (1991) p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res. 51, 4495–4499. CASPubMedWeb of Science®Google Scholar 109 Latif F., Fivash M., Glen G., Orcutt M.L., Hampsch K., Delisio J., Lerman M., Cowan J., Beckett M. & Weichselbaum R. (1992) Chromosome 3p deletions in head and neck carcinomas: statistical ascertainment of allelic loss. Cancer Rex 52, 1451–1456. PubMedWeb of Science®Google Scholar 110 Brauch H., Tory K., Kotler F., Gadzar A.F., Petengill O.S., Johnson B., Graziano S., Winton T., Buys C.H., Sorenson G.D., Poiesz B.J., Minna J.D. & Zbar B. (1990) Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer. Genes, Chrom. Cancer 1, 240–246. 10.1002/gcc.2870010309 CASPubMedWeb of Science®Google Scholar Citing Literature Volume18, Issue1February 1993Pages 4-13 ReferencesRelatedInformation

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