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Glucuronidation and its Role in Regulation of Biological Activity of Drugs

1992; Annual Reviews; Volume: 32; Issue: 1 Linguagem: Inglês

10.1146/annurev.pa.32.040192.000325

1545-4304

Gerard J. Mulder,

Pharmacogenetics and Drug Metabolism

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More