Produção Nacional
Revisado por pares
Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders
2013; Public Library of Science; Volume: 7; Issue: 7 Linguagem: Inglês
10.1371/journal.pntd.0002328
ISSN1935-2735
AutoresJordana Grazziela Alves Coelho-dos-Reis, Lívia Silva Araújo Passos, Mariana C. Duarte, Marcelo Grossi Araújo, Ana Carolina Campi‐Azevedo, Andréa Teixeira−Carvalho, Vanessa Peruhype-Magalhães, Bruno Caetano Trindade, Raquel dos Santos Dias, Marina Lobato Martins, Anna Bárbara de Freitas Carneiro-Proietti, Antônio Carlos Martins Guedes, Denise Utsch Gonçalves, Olindo Assis Martins‐Filho,
Tópico(s)Animal Disease Management and Epidemiology
ResumoIn the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4+HLA-DR+, CD8+ T cell, macrophage-like and NKT subsets as well as in the serum chemokines CCL5, CXCL8, CXCL9 and CXCL10 were observed in the HTLV-1-infected group with skin lesions. Additionally, HTLV-1 carriers with dermatological skin lesions showed more frequently high proviral load as compared to asymptomatic carriers. The elevated proviral load in HTLV-1 patients with infectious skin lesions correlated significantly with TNF-α/IL-10 ratio, while the same significant correlation was found for the IL-12/IL-10 ratio and the high proviral load in HTLV-1-infected patients with autoimmune skin lesions. All in all, these results suggest a distinct and unique immunological profile in the peripheral blood of HTLV-1-infected patients with skin disorders, and the different nature of skin lesion observed in these patients may be an outcome of a distinct unbalance of the systemic inflammatory response upon HTLV-1 infection.
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