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Finasteride in the treatment of men with frontal male pattern hair loss

1999; Elsevier BV; Volume: 40; Issue: 6 Linguagem: Inglês

10.1016/s0190-9622(99)70081-2

1097-6787

James L. Leyden, Frank Dunlap, Bruce Miller, Peter Winters, Mark Lebwohl, David Hecker, Stephen J. Kraus, Hilary Baldwin, Alan R. Shalita, Zoe Draelos, Michael Markou, Diane Thiboutot, Marvin J. Rapaport, Sewon Kang, Timothy L. Kelly, David M. Pariser, Guy Webster, Maria Hordinsky, Robert L. Rietschel, H. Irving Katz, Lisa Terranella, Sharon Best, Elizabeth Round, Joanne Waldstreicher,

Historical Gender and Feminism Studies

Abstract Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm 2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients ( P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth. (J Am Acad Dermatol 1999;40:930-7.)