Influence of aqueous extract of fenugreek-seed powder on the pharmacodynamics and pharmacokinetics of gliclazide in rats/rabbits
2007; Future Medicine; Volume: 4; Issue: 4 Linguagem: Inglês
10.2217/14750708.4.4.457
ISSN1744-831X
AutoresSreemantula Satyanarayana, Eswar Kumar Kilari, J. Rajasekhar, Leon Thomas, Sharada Rajanna, B. Rajanna,
Tópico(s)Diet, Metabolism, and Disease
ResumoBackground: Since drugs from oriental medicine are used along with allopathic drug therapy in highly populated countries, such as India and China, and since optimal blood-sugar control is needed in diabetes, a herbal drug that influences blood glucose was studied for its effect on gliclazide response in normal and diabetic rats and normal rabbits. Objective: To evaluate the safety of the herb–drug combination with respect to blood glucose in animal models. Methods: Blood-glucose levels were estimated by GOD/POD method using commercial glucose kits. The serum-gliclazide levels were estimated by HPLC method. Diabetes was induced in rats by intraperitoneal administration of alloxan monohydrate (100 mg and 50 mg/kg bodyweight for 2 consecutive days). Results: Gliclazide produced hypoglycemia in normal and diabetic rats with peak activity at 1 h and 8 h, and in rabbits at 3 h. Fenugreek-seed powder extract produced hypoglycemia when given alone and prolonged the effect of gliclazide in combination during 1–12 ...
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