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1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice

2011; Elsevier BV; Volume: 123; Issue: 1-3 Linguagem: Inglês

10.1016/j.drugalcdep.2011.11.001

1879-0046

Jenny L. Wiley, Julie A. Marusich, Billy R. Martin, John W. Huffman,

Forensic Toxicology and Drug Analysis

Smoking of synthetic cannabinoid-enhanced "herbal incense" is an emerging substance abuse problem. The indole-derived cannabinoids identified in these products were originally developed as research tools and are structurally distinct from cannabinoids in the cannabis plant. Although abused by humans, most published research on this class of compounds has been performed in vitro. The purpose of this study was to evaluate a novel series of 1-pentyl-3-phenylacetylindoles in mice.