Comparative replication capacity of raltegravir-resistant strains and antiviral activity of the new-generation integrase inhibitor dolutegravir in human primary macrophages and lymphocytes

Artigo Acesso aberto Revisado por pares

Comparative replication capacity of raltegravir-resistant strains and antiviral activity of the new-generation integrase inhibitor dolutegravir in human primary macrophages and lymphocytes

2014; Oxford University Press; Volume: 69; Issue: 9 Linguagem: Inglês

10.1093/jac/dku144

ISSN

1460-2091

Autores

Michela Pollicita, Matteo Surdo, F. Di Santo, María Francesca Cortese, Lavinia Fabeni, Valentina Fedele, Isabelle Malet, Anne‐Geneviève Marcelin, Vincent Cálvez, Francesca Ceccherini‐Silberstein, Carlo Federico Perno, Valentina Svicher,

Tópico(s)

Hepatitis C virus research

Resumo

ObjectivesTo evaluate the replication capacity and phenotypic susceptibility to dolutegravir and raltegravir of wild-type and raltegravir-resistant HIV-1 strains in several cellular systems.

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Comparative replication capacity of raltegravir-resistant strains and antiviral activity of the new-generation integrase inhibitor dolutegravir in human primary macrophages and lymphocytes