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Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen

2012; Wiley; Volume: 51; Issue: 52 Linguagem: Inglês

10.1002/anie.201206658

1521-3773

Katharina Graupner, Kirstin Scherlach, Tom Bretschneider, Gerald Lackner, Martin M. Roth, Harald Gross, Christian Hertweck,

Plant-Microbe Interactions and Immunity

Caught in the act: Imaging mass spectrometry of a button mushroom (see picture) infected with the soft rot pathogen Janthinobacterium agaricidamnosum in conjunction with genome mining revealed jagaricin as a highly antifungal virulence factor that is not produced under standard cultivation conditions. The structure of jagaricin was rigorously elucidated by a combination of physicochemical analyses, chemical derivatization, and bioinformatics.