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Levofloxacin in vitro activity and time-kill evaluation of Stenotrophomonas maltophilia clinical isolates

2000; Oxford University Press; Volume: 45; Issue: 1 Linguagem: Inglês

10.1093/jac/45.1.115

1460-2091

Giovanni Bonfiglio,

Bacterial biofilms and quorum sensing

The in vitro activity of levofloxacin and eight other antimicrobial agents against 60 clinical isolates of Stenotrophomonas maltophilia was determined by an agar dilution method using 104 and 106 cfu/spot inocula. At the lower inoculum, 85.0% of the isolates were susceptible to levofloxacin but only 58.3% were susceptible to ofloxacin; at the higher inoculum, 78.3% were susceptible to levofloxacin and 36.7% to ofloxacin. In time–kill studies, levofloxacin exerted bactericidal activity within 4 h. With ofloxacin and ciprofloxacin bacterial regrowth was observed after 8 h. Levofloxacin may represent an alternative drug in the treatment of infections caused by S. maltophilia.