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BIBTEX RIS

Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

2004; Elsevier BV; Volume: 80; Issue: 3 Linguagem: Inglês

10.2223/jped.1184

1678-4782

Charles K. Naspitz, Dirceu Sol eacute, Cristina A. Jacob, Emanuel Sarinho, Francisco José Passos Soares, Vera Maria Dantas, Márcia C. Mallozi, Neusa Falbo Wandalsen, Wellington Borges, Wilson Rocha Filho, Grupo PROAL,

Food Allergy and Anaphylaxis Research

Objective: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services.Patients and methods: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP ® Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched.RAST equal or higher than class 1 was considered as positive (R+).Results: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%).There were no differences according to gender.The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls.Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-.The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8%x 9.7% (p < 0.05), and cat = 12% x 8.1%.In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cows milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8%x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05).With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens.Conclusions: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients.Food allergens were also responsible for a significant proportion of sensitization, mainly in infants.