Produção Nacional
Revisado por pares
Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk
2013; Ferrata Storti Foundation; Volume: 99; Issue: 1 Linguagem: Inglês
10.3324/haematol.2013.083840
ISSN1592-8721
AutoresSuely Meireles Rezende, W.M. Lijfering, F.R. Rosendaal, Suzanne C. Cannegieter,
Tópico(s)Adipokines, Inflammation, and Metabolic Diseases
ResumoRecent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, monocytes, hematocrit, hemoglobin, erythrocytes and red cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width). We found a strong dose-response relation for higher red cell distribution width and monocyte count with risk of venous thrombosis, with odds ratios of 3.1 (95% confidence interval, 2.0–4.8) and 2.8 (95% confidence interval, 1.3–5.8), respectively, after adjustment for age, sex, C-reactive protein level, malignancy and co-morbidities. Monocyte count and red cell distribution width were associated with venous thrombosis even within reference ranges. A low monocyte count (
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