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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

A New Steroidal Saponin from Agave brittoniana and Its Biphasic Effect on the Na + -ATPase Activity

2005; De Gruyter; Volume: 60; Issue: 1-2 Linguagem: Inglês

10.1515/znc-2005-1-222

ISSN

1865-7125

Autores

Graziela M. Silva, Aloa Machado de Souza, Lucienne S. Lara, Tatiana P. Mendes, Bernadete Pereira da Silva, Aníbal Gil Lopes, Celso Caruso‐Neves, José Paz Parente,

Tópico(s)

Phytochemistry and Bioactive Compounds

Resumo

A new steroidal saponin, 3-{(O-6-deoxy-α-ʟ-mannopyranosyl-(1→4)-O-β-ᴅ-glucopyranosyl-( 1→3)-O-[O-β-ᴅ-glucopyranosyl-(1→3)-β-ᴅ-glucopyranosyl-(1→2)]-O-β-ᴅ-glucopyranosyl-( 1→4)-β-ᴅ-galactopyranosyl)oxy}-6-hydroxy-(3β,5α,6α,25R)-spirostan-12-one, was isolated from Agave brittoniana Trel. The structure was determined by extensive NMR spectroscopy studies and chemical conversions. Its effects on the Na + -ATPase and (Na + +K + )-ATPase activities of the proximal tubule from pig kidney were evaluated. It was observed that this steroidal saponin exerts a biphasic effect on the Na + -ATPase activity. It is concluded that the effect of the aqueous extract as a diuretic is due, at least in part, to the action of saponin on the ouabain-insensitive Na + -ATPase.

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