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HER-2/ neu Expression in Prostate Adenocarcinoma: A Systematic Review and Meta-Analysis

2010; Lippincott Williams & Wilkins; Volume: 184; Issue: 3 Linguagem: Inglês

10.1016/j.juro.2010.04.077

1527-3792

Ary Serpa Neto, Marcos Tobias‐Machado, Marcelo Langer Wroclawski, Fernando Luiz Affonso Fonseca, Gabriel Kushiyama Teixeira, Rodrigo Dal Moro Amarante, Eric Roger Wroclawski, Auro del Giglio,

Monoclonal and Polyclonal Antibodies Research

HER-2/neu has been linked to the clinical progression of hormone independent prostate cancer. We performed a meta-analysis to investigate the prognostic impact of HER-2/neu over expression in patients with prostate adenocarcinoma, and its correlation with other pathological and clinical variables.We searched the MEDLINE, Embase, CancerLit and ASCO abstract databases for published studies of HER-2/neu protein expression in primary prostate cancer tissue with a median followup of greater than 2 years and data on survival in patients with and without HER-2/neu over expression. We separately analyzed studies reporting HER-2/neu soluble receptor levels in patients with prostate cancer.We included 38 articles with a total of 5,976 patients. The overall RR of death in those with HER-2/neu over expression in the primary tumor was 1.63 (95% CI 1.47-1.82, p <0.0001). In the presence of over expression the recurrence RR was 1.87 (95% CI 1.59-2.21, p <0.0001). High HER-2/neu extracellular domain levels also correlated with death (RR 2.01, 95% CI 1.21-3.35, p = 0.007) and recurrence (RR 1.74, 95% CI 1.41-2.15, p <0.0001).There is a consistent association of HER-2/neu over expression and Gleason less than 7 with a higher RR of death and recurrence in patients with prostate cancer. Further clinical trials should test the hypothesis that HER-2/neu is a marker of a clinically worse outcome in patients with prostate cancer and a potential target for therapy.