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Steroidal and phenolic compounds from Sidastrum paniculatum (L.) Fryxell and evaluation of cytotoxic and anti-inflammatory activities

2010; Brazilian Chemical Society; Volume: 33; Issue: 4 Linguagem: Inglês

10.1590/s0100-40422010000400015

1678-7064

José Marcílio Sobral Cavalcante, Tiago Bezerra de Sá de Souza Nogueira, Anna Cláudia de Andrade Tomaz, Davi Antas e Silva, Maria de Fátima Agra, María de Fátima Vanderlei de Souza, Paulo Roberto Cavalcanti Carvalho, Sílvia Rafaelli Ramos, Silène Carneiro do Nascimento, Teresinha Gonçalves-Silva,

Phytochemical Studies and Bioactivities

Sidastrum paniculatum (L.) Fryxell belongs to the family Malvaceae and is popularly known as "malva roxa" or "malvavisco". The phytochemical study of the hexane, CHCl3 and EtOAc phases from the crude ethanol extract of S. paniculatum led to the isolation of six compounds: a mixture of β-sitosterol and stigmasterol, 4-methoxy-3-hydroxybenzoic acid, 4-methoxy-3-hydroxybenzaldehyde, N-trans-feruloyltyramine and kaempferol-3-O-β-D-(6''-E-p -coumaroyl) glucoside. The structural identification of the compounds was made on the basis of spectroscopic methods such as IR, ¹H and 13C NMR with the aid of including two-dimensional techniques, besides comparison with literature data. The β-sitosterol and stigmasterol mixture showed a significant anti-inflammatory activity.