Portal de Periódicos da CAPES

The APOL1 Genotype of African American Kidney Transplant Recipients Does Not Impact 5-Year Allograft Survival

2012; Elsevier BV; Volume: 12; Issue: 7 Linguagem: Inglês

10.1111/j.1600-6143.2012.04033.x

1600-6143

B.T Lee, Vineeta Kumar, Tom A. Williams, Reza Abdi, Andrea J. Bernhardy, Charissa A. Dyer, S Conte, Giulio Genovese, Michael D. Ross, David J. Friedman, Robert S. Gaston, Edgar L. Milford, Martin R. Pollak, Anil Chandraker,

Chronic Kidney Disease and Diabetes

Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 gene distributions on kidney allograft outcomes. We conducted a retrospective analysis of 119 AA kidney transplant recipients, and found that 58 (48.7%) carried two APOL1 kidney disease risk variants. Contrary to the association seen in native kidney disease, there is no difference in allograft survival at 5-year posttransplant for recipients with high-risk APOL1 genotypes. Thus, we were able to conclude that APOL1 genotypes do not increase risk of allograft loss after kidney transplantations, and carrying 2 APOL1 risk alleles should not be an impediment to transplantation.