Produção Nacional
Revisado por pares
GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
2010; Research Foundation of Ribeirão Preto; Volume: 9; Issue: 2 Linguagem: Inglês
10.4238/vol9-2gmr726
ISSN1676-5680
AutoresA.L. Oliveira, Fábio F. O. Rodrigues, Roberto Euzébio dos Santos, T. Aoki, Maurício Rocha, Carlos Alberto Longui, Mônica Barbosa de Melo,
Tópico(s)Epigenetics and DNA Methylation
ResumoThe glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione.We examined whether GSTT1/GSTT1"null", GSTM1/GSTM1"null" and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant chemotherapy in the treatment of stage II and III breast cancer.Forty Brazilian women with invasive ductal adenocarcinoma of the breast submitted to neoadjuvant chemotherapy, using 5-fluorouracil, epirubicin and cyclophosphamide, were genotyped for the GSTT1, GSTM1 and GSTP1 genes.Clinical
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