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The conformational locking of asparagine

2012; Royal Society of Chemistry; Volume: 48; Issue: 47 Linguagem: Inglês

10.1039/c2cc32109b

1364-548X

C. Cabezas, Marcelino Varela, Isabel Peña, Santiago Mata, Juan C. López, José L. Alonso,

Advanced Chemical Physics Studies

One dominant structure has been identified analysing the rotational spectrum of asparagine in sharp contrast with the multiconformational behaviour for other amino acids with polar side chains. This locking of the conformational variety to a single conformer has been ascribed to an intramolecular hydrogen bonding network involving α-amine, α-carboxylic and amide groups.