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Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

2015; Elsevier BV; Volume: 89; Issue: 2 Linguagem: Inglês

10.1016/j.lungcan.2015.05.013

1872-8332

Bihiyga Salhi, Christel Haenebalcke, Silvia Perez‐Bogerd, Mai D. Nguyen, Vincent Ninane, Thomas Malfait, Karim Vermaelen, Veerle Surmont, Georges Van Maele, Roos Colman, Eric Derom, Jan P. van Meerbeeck,

Fungal Infections and Studies

Introduction The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). Methods We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention. Results Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38 m (95% CI 22–54) and increased with a mean of 95 m (95% CI 58–132) in CRT (p < 0.0001), 37 m (95% CI −1–76) in WBVT (p = 0.06) and 1 m (95% CI −34–36) in CON (p = 0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54 m increase in 6MWD after intervention. Conclusions RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT.