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International Union of Pharmacology. LV. Nomenclature and Molecular Relationships of Two-P Potassium Channels

2005; American Society for Pharmacology and Experimental Therapeutics; Volume: 57; Issue: 4 Linguagem: Inglês

10.1124/pr.57.4.12

1521-0081

Steven A. Goldstein, Douglas A. Bayliss, Dong Hee Kim, Florian Lesage, Leigh D. Plant, Sindhu Rajan,

Cardiac electrophysiology and arrhythmias

In less than a decade since their discovery, the study of K2P channels has revealed that background leak of potassium ions via dedicated pathways is a highly regulated mechanism to control cellular excitability. Potassium leak pathways, active at rest, stabilize membrane potential below firing