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Three Diterpenoids (Excoecarins V1-V3) and a Flavanone Glycoside from the Fresh Stem of Excoecaria agallocha

2003; Pharmaceutical Society of Japan; Volume: 51; Issue: 10 Linguagem: Inglês

10.1248/cpb.51.1142

ISSN

1347-5223

Autores

Tenji Konishi, Kiyonori Yamazoe, Masahiro Kanzato, Takao Konoshima, Yasuhiro Fujiwara,

Tópico(s)

Biological Activity of Diterpenoids and Biflavonoids

Resumo

Three new diterpenoids, excoecarins V1-V3 (1-3) and a new flavanone glycoside (7) were isolated from the fresh stem of Excoecaria agallocha L. Their structures were elucidated as: 2alpha,3alpha,18-trihydroxy-3beta,20-epoxybeyer-15-ene (1), ent-2,3-secokaur-16-en-2,3-dioic acid (2), ent-3,4-seco-16alpha-hydroxyatis-4(19)-en-3-oic acid (3), and 3,5,7,3',5'-pentahydroxy-2R,3R-flavanonol 3-O-alpha-L-rhamnopyranoside (7) on the basis of spectroscopic data, chemical evidence, and/or X-ray analysis.

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