Produção Nacional
Revisado por pares
Resveratrol provoca efeitos antiaterogênicos em um modelo animal de aterosclerose
2012; Sociedade Brasileira de Cardiologia (SBC); Volume: 98; Issue: 2 Linguagem: Inglês
10.1590/s0066-782x2012005000006
ISSN1678-4170
AutoresRossane Serafim Matos, Lis Andréa Villela Baroncini, Leonardo Brandão Précoma, Guilherme Winter, Pedro Henrique Lambach, Caron, Flávia Kaiber, Dalton Bertolim Précoma,
Tópico(s)Adipose Tissue and Metabolism
ResumoResveratrol protects the cardiovascular system by a number of mechanisms, including antioxidant and anti-platelet activities.To assess the potential anti-inflammatory and antiatherogenic effects of resveratrol using rabbits fed a hypercholesterolemic diet (1% cholesterol).Twenty white male rabbits were selected and divided into two groups: control group (CG), 10 rabbits; and resveratrol group (RG), 10 rabbits. The animals were fed a hypercholesterolemic diet for 56 days. For the RG diet, resveratrol (2 mg/kg weight/day) was added from days 33-56.There was no significant difference in the total serum cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides between the groups. Of the CG, 70% had advanced aortic atherosclerotic lesions (types III, IV, V, or VI). All animals from the RG had mild aortic atherosclerotic lesions (types I or II, or no lesions). The intima area and the intima/media layer area ratio was significantly lower in the RG as compared to the CG (p<0.001). Positive areas for VCAM-1 molecules were lower in the RG (p=0.007). The MCP-1 and IL-6 concentrations were lower in the RG than the CG (p=0.039 and p=0.015, respectively).Resveratrol had significant anti-atherogenic and anti-inflammatory effects in an animal model with rabbits fed a hypercholesterolemic diet (1% cholesterol).
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