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Stereoselective Total Synthesis of Epothilones by the Metathesis Approach Involving C9−C10 Bond Formation

2002; Wiley; Volume: 41; Issue: 8 Linguagem: Inglês

10.1002/1521-3773(20020415)41

1521-3773

Jian Sun, Subhash C. Sinha,

Advanced Synthetic Organic Chemistry

Angewandte Chemie International EditionVolume 41, Issue 8 p. 1381-1383 Communication Stereoselective Total Synthesis of Epothilones by the Metathesis Approach Involving C9−C10 Bond Formation Jian Sun Dr., Jian Sun Dr. Department of Molecular Biology and the Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-8732Search for more papers by this authorSubhash C. Sinha Prof., Subhash C. Sinha Prof. subhash@scripps.edu Department of Molecular Biology and the Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-8732Search for more papers by this author Jian Sun Dr., Jian Sun Dr. Department of Molecular Biology and the Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-8732Search for more papers by this authorSubhash C. Sinha Prof., Subhash C. Sinha Prof. subhash@scripps.edu Department of Molecular Biology and the Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-8732Search for more papers by this author First published: 16 April 2002 https://doi.org/10.1002/1521-3773(20020415)41:8 3.0.CO;2-OCitations: 36 We are thankful to Professor Richard A. Lerner and Samuel J. Danishefsky for helpful discussions. This research was funded by the Scripps Research Institute and the Skaggs Institute for Chemical Biology. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A stereoselective synthesis of epothilone B was achieved by the metathesis of the diene 1, by use of a new Grubbs catalyst to form the C9−C10 bond, followed by hydrogenation and deprotection of 2; TBS=tert-butyldimethylsilyl. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z17798_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume41, Issue8April 15, 2002Pages 1381-1383 RelatedInformation