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Prognostic Significance of Interactions Between ER Alpha and ER Beta and Lymph Node Status in Breast Cancer Cases

2013; West Asia Organization for Cancer Prevention; Volume: 14; Issue: 10 Linguagem: Inglês

10.7314/apjcp.2013.14.10.6081

2476-762X

Shu‐Jing Han, Qingqing Guo, Ting Wang, Youxin Wang, Yuxiang Zhang, Fen Liu, Yanxia Luo, Jie Zhang, Youli Wang, Yuxiang Yan, Xiaoxia Peng, Rui Ling, Yan He,

Nuclear Receptors and Signaling

Objective: Both estrogen receptors, ER alpha ( $ER{\alpha}$ ) and ER beta ( $ER{\beta}$ ), are expressed in 50-70% of breast cancer cases. The role of $ER{\alpha}$ as a prognostic marker in breast cancer has been well established as its expression is negative correlated with tumor size and lymph node metastasis. $ER{\beta}$ is also a favorable prognostic predictor although this is less well documented than for $ER{\alpha}$ . Materials and Methods: To explore whether ERs independently or together might influence clinical outcome in breast cancer, the correlation between the ERs with the clinicopathological features was analyzed in 84 patients. Results: $ER{\alpha}$ expression negatively correlated with tumor stage (r=-0.246, p=0.028) and tended to be negatively correlated with lymph node status (r=-0.156, p=0.168) and tumor size (r=-0.246, p=0.099). Also, $ER{\beta}$ was negatively correlated with nodal status (r=-0.243, p=0.028), as was coexpression of $ER{\alpha}$ and $ER{\beta}$ (p=0.043, OR=0.194, 95% CI= 0.040-0.953). Conclusion: Coexpression of ERs might serve as an indicator of good prognosis in breast cancer patients.