Anti-Spasmogenic Effects of Bencianol (ZY15051 on Human Cerebral Arteries In Vitro
1985; SAGE Publishing; Volume: 5; Issue: 4 Linguagem: Inglês
10.1046/j.1468-2982.1985.0504217.x
ISSN1468-2982
AutoresE T Whalley, KS Paul, O D Gulati,
Tópico(s)Heart Rate Variability and Autonomic Control
ResumoExperiments were performed to assess the ability of bencianol (ZY15051) to reverse contractions of human basilar arteries in vitro that were induced by a wide range of substances implicated in the aetiology of migraine and cerebral arterial spasm. Bencianol caused a dose-related (1-100 micrograms ml-1) reversal of contractions induced by 5-hydroxytryptamine, noradrenaline, angiotensin II, prostaglandin F2 alpha, and U-46619 (a thromboxane-A2 mimetic). Bencianol was more effective against contractions induced by EC50 compared to maximal concentrations of each agent, and was least effective against the thromboxane-A2 mimetic, U-46619. In addition, contractions induced by thromboxane-A2-like substances generated from guinea-pig lungs were also reversed by bencianol but only at the highest concentration used (100 micrograms ml-1). The relevance of this action of bencianol to migraine and cerebral arterial spasm is discussed.
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