Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy

2006; American Society for Microbiology; Volume: 75; Issue: 3 Linguagem: Inglês

10.1128/iai.01326-06

ISSN

1098-5522

Autores

Heloísa D’Ávila, Patrícia E. de Almeida, Natália R. Roque, Hugo C. Castro‐Faria‐Neto, Patrı́cia T. Bozza,

Tópico(s)

Immune Cell Function and Interaction

Resumo

ABSTRACT An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.

Referência(s)