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Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don) XXXVI: Isolation and Characterization of New Dimeric Alkaloids

1975; Elsevier BV; Volume: 64; Issue: 12 Linguagem: Inglês

10.1002/jps.2600641209

1520-6017

Susan Tafur, William E. Jones, Douglas E. Dorman, E. E. Logsdon, Gordon H. Svoboda,

Synthesis and bioactivity of alkaloids

In a continuing effort to study thoroughly the alkaloids of Catharanthus roseus, new dimeric alkaloids were isolated and characterized. Structures are proposed for leurocolombine and vinamidine based on UV, IR, PMR, high‐resolution mass spectrometry, and CMR. Pseudovincaleukoblastine diol was identified by PMR and mass spectrometry. Leurocolombine exhibited antimitotic activity and marginal antitumor activity against the Ridgeway osteogenic sarcoma.