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Retinal Stem Cells in the Adult Mammalian Eye

2000; American Association for the Advancement of Science; Volume: 287; Issue: 5460 Linguagem: Inglês

10.1126/science.287.5460.2032

1095-9203

Vincent Tropepe, Brenda L.K. Coles, Bernard J. Chiasson, D. Jonathan Horsford, Andrew Elia, Roderick R. McInnes, Derek van der Kooy,

Neurogenesis and neuroplasticity mechanisms

The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which represents a possible substrate for retinal regeneration. Single pigmented ciliary margin cells clonally proliferate in vitro to form sphere colonies of cells that can differentiate into retinal-specific cell types, including rod photoreceptors, bipolar neurons, and Müller glia. Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.