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The Matrix Reloaded: New Insights from Type IV Collagen Derived Endogenous Angiogenesis Inhibitors and their Mechanism of Action

2009; OMICS Publishing Group; Volume: 01; Issue: 02 Linguagem: Inglês

10.4172/jbb.1000009

0975-0851

Akulapalli Sudhakar,

Protease and Inhibitor Mechanisms

Angiogenesis, the process of neovascularization from parent blood vessels, is a prerequisite for many physiological and pathological conditions that is regulated by a balance between the levels of endogenous angiogenic stimulators and matrix reloaded angiogenic regulators.Several non-collagenous carboxy terminal end domains in chains of type IV collagen matrix reloaded molecules selectively interact with proliferating endothelial cells by binding to distinct integrins and regulate intracellular signaling and inhibit angiogenesis.This review will focus on the current understanding of extra cellular matrix type IV collagen reloaded endogenous angiogenesis inhibitors and their mechanism of action.