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Beating Poisson encapsulation statistics using close-packed ordering

2009; Royal Society of Chemistry; Volume: 9; Issue: 18 Linguagem: Inglês

10.1039/b909386a

1473-0197

Adam R. Abate, Chia‐Hung Chen, Jeremy J. Agresti, David A. Weitz,

Microfluidic and Bio-sensing Technologies

Loading drops with discrete objects, such as particles and cells, is often necessary when performing chemical and biological assays in microfluidic devices. However, random loading techniques are inefficient, yielding a majority of empty and unusable drops. We use deformable particles that are close packed to insert a controllable number of particles into every drop. This provides a simple, flexible means of efficiently encapsulating a controllable number of particles per drop.