Produção Nacional
Revisado por pares
Pterodon pubescens benth: stability study of microencapsulated extract and isolated compounds monitored by antinociceptive assays
2012; Brazilian Chemical Society; Volume: 23; Issue: 7 Linguagem: Inglês
10.1590/s0103-50532012000700008
ISSN1678-4790
AutoresLeila Servat, Humberto M. Spindola, Rodney Alexandre Ferreira Rodrigues, Ilza Maria de Oliveira Sousa, Ana Lúcia Tasca Góis Ruiz, João Ernesto de Carvalho, Mary Ann Foglio,
Tópico(s)Plant-Derived Bioactive Compounds
ResumoPterodon pubescens Benth. (Pp) seeds, commercially available in Brazil, are used in folk medicine in anti-inflammatory, analgesic, and anti-rheumatic preparations. The present study demonstrated the antinociceptive properties of isomers 6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester (C1), isolated from (Pp), employing different experimental models. A stability study was performed to investigate the relationship of microencapsulation by spray-drying on the maintenance of antinociceptive action. Therefore, C1 and Pp extract samples were monitored in accelerated stability study, evaluating both microencapsulated and non-microencapsulated samples. It was observed that sample C1 possess antinociceptive activity revealed by writhing and formalin tests; C1 showed significantly anti-allodynic, but not antihyperalgesic effect; the microencapsulation maintained the activity and integrity of both, sample C1 and Pp crude extract; microencapsulation by spray drying is a useful alternative to increase shelf life.
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