Asymmetric Mukaiyama-Aldol Reaction in Aqueous Media Promoted by Zinc-Based Chiral Lewis Acids
2005; Wiley; Volume: 347; Issue: 4 Linguagem: Inglês
10.1002/adsc.200404314
ISSN1615-4169
AutoresJacek Młynarski, Joanna Jankowska,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoAsymmetric aldol reactions in aqueous media have been realized by using zinc-based chiral Lewis acids. The aldol products have been obtained with high yield, diastereocontrol and a good level of enantioselectivity. The reactivity of both acetophenone and propiophenone enol ether surrogates was tested with a range of aldehydes.
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