dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
2012; American Association for the Advancement of Science; Volume: 337; Issue: 6093 Linguagem: Inglês
10.1126/science.1223899
ISSN1095-9203
AutoresJeannette M. Osterloh, Jing Yang, Timothy M. Rooney, A. Nicole Fox, Róbert Adalbert, Eric Powell, Amy E. Sheehan, Michelle A. Avery, Rachel Hackett, Mary A. Logan, Jennifer M. MacDonald, Jennifer S. Ziegenfuss, Stefan Milde, Ying-Ju Hou, Carl Nathan, Aihao Ding, Robert H. Brown, Laura Conforti, Michael P. Coleman, Marc Tessier‐Lavigne, Stephan Züchner, Marc Freeman,
Tópico(s)Axon Guidance and Neuronal Signaling
ResumoSarm-Assisted Suicide Neurodegenerative disease or nerve lesions cause axons and synapses to disintegrate through a process known as Wallerian degeneration, which may involve an active “axon death program.” Osterloh et al. (p. 481 , published online 7 June; see the Perspective by Yu and Luo ) identify loss-of-function mutations in Drosophila dSarm that are capable of blocking the degeneration of severed axons for the fly life span. Deletion of mouse Sarm1 provides similar protection to severed axons for weeks after injury, which suggests that Sarm is part of an ancient axonal death signaling cascade.
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