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Towards a Structural Basis for the Relationship Between Blood Group and the Severity of El Tor Cholera

2012; Wiley; Volume: 51; Issue: 21 Linguagem: Inglês

10.1002/anie.201109068

1521-3773

Pintu Kumar Mandal, Thomas R. Branson, Edward D. Hayes, James F. Ross, José A. Gavín, Antonio Hernández Daranas, W. Bruce Turnbull,

Bacterial Genetics and Biotechnology

It has long been known that people with blood group O are more severely affected by El Tor cholera than those with blood groups A or B. Microcalorimetry and NMR spectroscopy are used to evaluate the ability of the B-subunits of cholera toxin and E. coli heat-labile toxin to bind to selected blood group oligosaccharides.