Portal de Periódicos da CAPES

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

2014; Nature Portfolio; Volume: 14; Issue: 2 Linguagem: Inglês

10.1038/nrc3655

1474-1768

Dominik Sturm, Sebastian Bender, David Jones, Peter Lichter, Jacques Grill, Oren J. Becher, Cynthia Hawkins, Jacek Majewski, Chris Jones, J Costello, Antonio Iavarone, Kenneth Aldape, Cameron Brennan, Nada Jabado, Stefan M. Pfister,

Epigenetics and DNA Methylation

The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups. These studies have highlighted key distinctions, but also some commonalities, which are discussed in this Review. We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.