Artigo Revisado por pares

Furosemide accumulation by renal tissue

1975; Elsevier BV; Volume: 24; Issue: 21 Linguagem: Inglês

10.1016/0006-2952(75)90379-2

ISSN

1873-2968

Autores

G. H. Hirsch, Attila Pakuts, Alexander J. Bayne,

Tópico(s)

Pharmacological Effects and Toxicity Studies

Resumo

Furosemide accumulation by rabbit kidney cortical slices increased with incubation time, reaching a plateau by 60–90 min. Furosemide uptake by kidney slices from rabbits, dogs, mice and rats was inhibited by dinitrophenol, ouabain and probenecid, and was decreased by incubation at 0°, anoxia or the use of sodium-free medium. Furosemide slice/medium ratios decreased with increasing concentration of furosemide in the incubation medium. Addition of furosemide to medium containing rat kidney slices and either p-aminohippurate (PAH) or N-methylnicotinamide (NMN) produced a dose-related inhibition of PAH, but not NMN, accumulation. It is concluded that furosemide is actively transported by the renal organic anion transport system.

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