Furosemide accumulation by renal tissue
1975; Elsevier BV; Volume: 24; Issue: 21 Linguagem: Inglês
10.1016/0006-2952(75)90379-2
ISSN1873-2968
AutoresG. H. Hirsch, Attila Pakuts, Alexander J. Bayne,
Tópico(s)Pharmacological Effects and Toxicity Studies
ResumoFurosemide accumulation by rabbit kidney cortical slices increased with incubation time, reaching a plateau by 60–90 min. Furosemide uptake by kidney slices from rabbits, dogs, mice and rats was inhibited by dinitrophenol, ouabain and probenecid, and was decreased by incubation at 0°, anoxia or the use of sodium-free medium. Furosemide slice/medium ratios decreased with increasing concentration of furosemide in the incubation medium. Addition of furosemide to medium containing rat kidney slices and either p-aminohippurate (PAH) or N-methylnicotinamide (NMN) produced a dose-related inhibition of PAH, but not NMN, accumulation. It is concluded that furosemide is actively transported by the renal organic anion transport system.
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