Portal de Periódicos da CAPES

Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons

2010; Optica Publishing Group; Volume: 35; Issue: 3 Linguagem: Inglês

10.1364/ol.35.000369

1539-4794

Mark Niedre, Vasilis Ntziachristos,

Non-Invasive Vital Sign Monitoring

The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2-3, yielding a significant improvement in the tomographic image reconstruction quality.