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The control and facilitation of MHC class II antigen processing by the BCR

2001; Elsevier BV; Volume: 13; Issue: 1 Linguagem: Inglês

10.1016/s0952-7915(00)00178-3

1879-0372

Karyn F. Siemasko, Marcus R. Clark,

T-cell and B-cell Immunology

Antigens capable of cross-linking the BCR are preferentially captured, processed and presented to MHC-class-II-restricted T cells. Cross-linking antigens initiate tyrosine-kinase-dependent pathways that accelerate the delivery of antigen–receptor complexes to specialized late-endocytic processing compartments. Accelerated trafficking is mediated by the recruitment of signaling molecules required for transience through specific checkpoints along the endocytic pathway.