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Glycosylation of Tetraspanin Tspan-1 at Four Distinct Sites Promotes Its Transition Through the Endoplasmic Reticulum

2009; Bentham Science Publishers; Volume: 16; Issue: 10 Linguagem: Inglês

10.2174/092986609789071234

1875-5305

Claus Jürgen Scholz, Georg Sauer, Helmut Deißler,

Caveolin-1 and cellular processes

We showed that Tspan-1, a tetraspanin overexpressed in many human cancers, harbours oligosaccharides at all four potential N-glycosylation sites. Its most abundant form contained only mannose-rich sugar chains but two distinct glycosylation sites could also contain complex carbohydrates. Glycosylation seemed to be required for correct folding and subsequent transition through the endoplasmic reticulum.