Transition-metal-mediated reactions in combinatorial synthesis
1998; Elsevier BV; Volume: 2; Issue: 3 Linguagem: Inglês
10.1016/s1367-5931(98)80009-4
ISSN1879-0402
AutoresCJ Andres, Darren L. Whitehouse, Milind Deshpande,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoTransition-metal-mediated reactions have played an important role in expanding the scope of combinatorial chemistry from synthesis of peptidic libraries to synthesis of nonoligomeric, small-molecule libraries. Versatile reactions such as heteroannulations, olefin metathesis and dipolar cycloadditions are used for preparation of libraries of historical, as well as novel, pharmacophores. Transition-metal-mediated reactions have also been used strategically to provide ‘traceless linkers’ in solid-phase synthesis.
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