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Consistent Fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

1999; Elsevier BV; Volume: 113; Issue: 1 Linguagem: Inglês

10.1016/s0165-4608(99)00007-2

1873-4456

Melina Carapeti, Ricardo C.T. Aguiar, A. E. Watmore, John M. Goldman, Nicholas C.P. Cross,

Chromatin Remodeling and Cancer

We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16) (p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13).