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Lewis Acid‐Catalyzed Direct Amination of Benzhydryl Alcohols

2006; Wiley; Volume: 348; Issue: 15 Linguagem: Inglês

10.1002/adsc.200600236

1615-4169

Vincent Terrasson, Sylvain R. A. Marque, Marie Georgy, Jean‐Marc Campagne, Damien Prim,

Asymmetric Synthesis and Catalysis

Abstract The Lewis acid‐mediated direct amination of benzylic alcohols is described, providing various benzylic amine derivatives in good yields under mild and environmentally benign conditions. Among the different Lewis acids tested, gold(III) proved to be the catalyst of choice for both chemical (yield, conversion) and practical reasons (a filtration over a silica pad is generally sufficient to obtain the corresponding benzylic amine in analytically pure form).