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Comparative Pharmacokinetics of Coumarin Anticoagulants XXV: Warfarin–Ibuprofen Interaction in Rats

1977; Elsevier BV; Volume: 66; Issue: 7 Linguagem: Inglês

10.1002/jps.2600660710

1520-6017

John T. Slattery, Avraham Yacobi, Gerhard Levy,

Pesticide Residue Analysis and Safety

The effect of ibuprofen on the pharmacokinetics and anticoagulant action of racemic warfarin was determined in a crossover study on male Sprague-Dawley rats. At average plasma concentrations of 24–83 mg/liter, ibuprofen decreased the biological half-life and increased the total clearance of warfarin. It also increased the anticoagulant effect produced by a given plasma concentration of total (free and protein- bound) warfarin. These effects of ibuprofen appear to be a consequence of its displacing effect on warfarin in plasma.