Portal de Periódicos da CAPES

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

2013; American Association for the Advancement of Science; Volume: 6; Issue: 269 Linguagem: Inglês

10.1126/scisignal.2004088

1937-9145

Jianjiong Gao, Bülent Arman Aksoy, Uğur Doğrusöz, Gideon Dresdner, Benjamin Groß, S. Onur Sumer, Yichao Sun, Anders J. Skanderup, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, Nikolaus Schultz,

Gene expression and cancer classification

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.